F1 racing driver Lewis and stunning singer and US X Factor judge Nicole, who met at the MTV Awards in Munich in 2007, have called time on their relationship.
They have parted before, in January this year, citing work issues — but pals say this time they are treating it as final.
A source said: "Nicole and Lewis have tried to make it work but realised it's just not happening so have called it a day once and for all.
"They've spoken at length about it but agreed there's no point as they never see each other. They spend their whole time on opposite sides of the world.
"Although they came to an amicable decision, Nicole is actually devastated about it. She thought Lewis was the one."
Nicole, 33, has been juggling her time between seeing Lewis, 26, and her many work commitments.
In the past year the Hawaiian-born beauty has released and promoted debut solo album Killer Love, filmed her part in Men In Black III and landed the job as a judge on US X Factor.
Meanwhile Lewis, who has appeared unsettled in recent weeks, has been touring the globe with his F1 team McLaren.
Following a miserable run of results, Hamilton was back on the podium last Sunday after coming second at the Korean Grand Prix.
As well as their careers keeping them apart he is based in the Swiss city of Geneva whereas Nicole has a home in the Hollywood Hills.
The pair have previously spoken of their future together. But last month Lewis batted away the suggestion of starting a family, saying: "I'm still young. It's a long way away."
A source added: "They still genuinely care for each other but they've decided to be adult about it and go it alone. There are no hard feelings."
